Dp(16Dyrk1a-B3galt5)5TybEmcf Cytogenetic Marker Detail

Summary

• Symbol
  Dp(16Dyrk1a-B3galt5)5TybEmcf
• Name
  duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 5

• Feature Type
  chromosomal duplication
• IDs
  MGI:5703857

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 16, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  1 strains or lines available

Mice exhibit partial lethality with congenital heart defects including OAA, DORV, VSD and ASD.

References

• Summaries
  All 3

  Phenotypes 3
• Earliest
  J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• Latest
  J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077