Tg(Prnp-ATXN7*92Q)1963Als
Transgene Detail

Summary

• Symbol: Tg(Prnp-ATXN7*92Q)1963Als
• Name: transgene insertion 1963, Albert R La Spada
• MGI ID: MGI:5705123
• Synonyms: Sca7
• Transgene: Tg(Prnp-ATXN7*92Q)1963Als Location: unknown
• Alliance: Tg(Prnp-ATXN7*92Q)1963Als page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-ATXN7*92Q)1963Als expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATXN7 (6314)

  Atxn7

  (MGI:2179277)

• Mutation details: The coding region of the human gene containing 92 CAG repeats is under the control of the murine prion protein promoter. N-terminal FLAG and C-terminal c-myc epitope tags were also added. Western blot analysis confirmed the expression of the full-length protein in the cerebellum and retina. (J:222402)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:222402 Guyenet SJ, et al., Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Hum Mol Genet. 2015 Jul 15;24(14):3908-17
• All: 1 reference(s)