About   Help   FAQ
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Transgene Detail
Summary
Symbol: Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Name: transgene insertion 17, Tsutomu Tanabe
MGI ID: MGI:5705582
Synonyms: Cav2.2KD, Tg(Itgam-cre/ERT2,RNU6-RNAi:Cacna1b)17Ttan
Transgene: Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan  Location: unknown  
Alliance: Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inducible, Knockdown, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
  Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan involves 1 genes/genome features (Cacna1b) View all
 
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan expression driven by 1 gene
 
Mutation detailsThe transgene is composed of the human RNU6 promoter disrupted by a floxed neomycin resistance cassette, short-hairpin RNA targeting Cacna1b, the human GH sequence, and the mouse Itgam promoter driving expression of an inducible cre recombinase gene (cre/ERT2) in microglial/macrophage cells. Five founders were generated and line 17 was selected as the representative line. (J:221994)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Itgam (mouse)
Summary of all recombinase alleles driven by Itgam.
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:221994 Saegusa H, et al., N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem Biophys Res Commun. 2014 Jul 18;450(1):142-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory