Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Transgene Detail
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Symbol: |
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan |
Name: |
transgene insertion 17, Tsutomu Tanabe |
MGI ID: |
MGI:5705582 |
Synonyms: |
Cav2.2KD, Tg(Itgam-cre/ERT2,RNU6-RNAi:Cacna1b)17Ttan |
Transgene: |
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan Location: unknown
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Alliance: |
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan page
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Transgene Type: |
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Transgenic (Inducible, Knockdown, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan involves 1 genes/genome features (Cacna1b)
View all
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Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Itgam (MGI:96607) |
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Mutation details: The transgene is composed of the human RNU6 promoter disrupted by a floxed neomycin resistance cassette, short-hairpin RNA targeting Cacna1b, the human GH sequence, and the mouse Itgam promoter driving expression of an inducible cre recombinase gene (cre/ERT2) in microglial/macrophage cells. Five founders were generated and line 17 was selected as the representative line.
(J:221994)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Itgam
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:221994 Saegusa H, et al., N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem Biophys Res Commun. 2014 Jul 18;450(1):142-7 |
All: |
3 reference(s) |
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