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Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Transgene Detail
Summary
Symbol: Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan
Name: transgene insertion 17, Tsutomu Tanabe
MGI ID: MGI:5705582
Synonyms: Cav2.2KD, Tg(Itgam-cre/ERT2,RNU6-RNAi:Cacna1b)17Ttan
Transgene: Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan  Location: unknown  
Alliance: Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan page
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inducible, Knockdown, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
  Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan involves 1 genes/genome features (Cacna1b) View all
 
Tg(Itgam-cre/ERT2,U6-RNAi:Cacna1b)17Ttan expression driven by 1 gene
 
Mutation detailsThe transgene is composed of the human RNU6 promoter disrupted by a floxed neomycin resistance cassette, short-hairpin RNA targeting Cacna1b, the human GH sequence, and the mouse Itgam promoter driving expression of an inducible cre recombinase gene (cre/ERT2) in microglial/macrophage cells. Five founders were generated and line 17 was selected as the representative line. (J:221994)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Itgam (mouse)
Summary of all recombinase alleles driven by Itgam.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:221994 Saegusa H, et al., N-type voltage-dependent Ca2+ channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem Biophys Res Commun. 2014 Jul 18;450(1):142-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory