Tg(Cd4-NPM/ALK)N1Ingh
Transgene Detail

Summary

• Symbol: Tg(Cd4-NPM/ALK)N1Ingh
• Name: transgene insertion N1, Giorgio Inghirami
• MGI ID: MGI:3833917
• Synonyms: CD4/NPM-ALK, NPM-ALK Tg
• Transgene: Tg(Cd4-NPM/ALK)N1Ingh Location: unknown
• Alliance: Tg(Cd4-NPM/ALK)N1Ingh page

Transgene origin

• Strain of Origin: Swiss Webster

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cd4-NPM/ALK)N1Ingh expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALK (238)

  Alk	(MGI:103305)

  Transgene codes for fusion protein of human NPM1 and ALK.

  human

  NPM1 (4869)

  Npm1	(MGI:106184)

  Transgene codes for fusion protein of human NPM1 and ALK.

• Mutation details: A construct expressing the full-length cDNA of a human NPM-ALK chimeric fusion gene was placed under the control of the murine CD4 promoter. The transgenic cassette (CD4 cassette) included the minimal CD4 enhancer (339 base pair [bp]), the minimal murine CD4 promoter (487 bp), the transcription initiation site, and 70 bp of the untranslated first exon and part of the first intron of the murine CD4 gene, but lacked the CD8 silencer. The fusion gene is expressed in T lymphocytes. Transgenic founder line N1 is representative of two additional lines studied, N14 and N16. (J:82127)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Anaplastic Large Cell Lymphoma J: 235890 in double Tg(Cd4-NPM/ALK)N1Ingh and Tg(TcraTcrb)1100Mjb mice.

References

• Original: J:82127 Chiarle R, et al., NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood. 2003 Mar 1;101(5):1919-27
• All: 11 reference(s)