Tg(Camk2a-MAPT)601Ymot
Transgene Detail

Summary

• Symbol: Tg(Camk2a-MAPT)601Ymot
• Name: transgene insertion 601, Yumiko Motoi
• MGI ID: MGI:5749788
• Synonyms: Tg601
• Transgene: Tg(Camk2a-MAPT)601Ymot Location: unknown
• Alliance: Tg(Camk2a-MAPT)601Ymot page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-MAPT)601Ymot expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: An 8.5 kb portion of the calcium/calmodulin-dependent protein kinase II-alpha promoter containing upstream control regions and the transcriptional initiation site drives the expression of a human wild-type tau cDNA in forebrain neurons. Western blot confirmed expression in the brain and that tau becomes hyperphosphorylated with increasing age. (J:172762)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:172762 Kambe T, et al., Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiol Dis. 2011 Jun;42(3):404-14
• All: 3 reference(s)