Rr38 Other Genome Feature Detail

Summary

• Symbol
  Rr38
• Name
  regulatory region 38
• Synonyms
  medionasal enhancer, MNE, N-Me, Notch Myc enhancer

• Feature Type
  enhancer
• IDs
  MGI:5750929

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• chr15:63127133-63128253 (GRCm39) derived from Rr38 deletion loxP sites

• Genetic Map
  Chromosome 15, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  11 phenotypes from 1 allele in 1 genetic background
  4 phenotype references
  

• All Mutations and Alleles
  7
• Targeted
  2
• Transposon induced
  5
• Genomic Mutations
  5 involving Rr38
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for a knock-out allele exhibit hypoplastic thymi, decreased single positive T cells and increased DN3 thymocytes.

References

• Summaries
  All 5

  Phenotypes 4
• Earliest
  J:180121 Ruf S, et al., Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor. Nat Genet. 2011 Apr;43(4):379-86
• Latest
  J:257739 Bahr C, et al., A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies. Nature. 2018 Jan 25;553(7689):515-520