Tg(tetO-FMR1*,-EGFP)#Rkhu
Transgene Detail

Summary

• Symbol: Tg(tetO-FMR1*,-EGFP)#Rkhu
• Name: transgene insertion, Renate K Hukema
• MGI ID: MGI:5751860
• Synonyms: 90CGG, TRE-90CGC-eGFP
• Transgene: Tg(tetO-FMR1*,-EGFP)#Rkhu Location: unknown
• Alliance: Tg(tetO-FMR1*,-EGFP)#Rkhu page

Transgene origin

• Strain of Origin: C57BL/6JRj

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-FMR1*,-EGFP)#Rkhu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FMR1 (2332)

  Fmr1	(MGI:95564)

• Mutation details: Human FMR1 5' UTR containing 90 CGG repeats and enhanced green fluorescent protein are under the control of the tetracycline responsive promoter element. (J:229379)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:229379 Hukema RK, et al., Induced expression of expanded CGG RNA causes mitochondrial dysfunction in vivo. Cell Cycle. 2014;13(16):2600-8
• All: 4 reference(s)