Tg(Alb-HBx)A112Tfts
Transgene Detail

Summary

• Symbol: Tg(Alb-HBx)A112Tfts
• Name: transgene insertion A112, Ting-Fen Tsai
• MGI ID: MGI:5755963
• Transgene: Tg(Alb-HBx)A112Tfts Location: unknown
• Alliance: Tg(Alb-HBx)A112Tfts page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The mouse albumin promoter drives the expression of the X gene of the Hepatitis B virus ayw subtype in the liver. Two direct repeats of the chicken beta-globin HS4 insulator were placed downstream of the poly(A) signal to block positional effects. four lines were established: A105, A106, A110, and A112. This is a high expression line with 1 transgenic copy number. A high level of Hepatitis B virus mRNA expression is detected in the liver and a lower level in the kidney. (J:104728)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:104728 Wu BK, et al., Blocking of G1/S transition and cell death in the regenerating liver of Hepatitis B virus X protein transgenic mice. Biochem Biophys Res Commun. 2006 Feb 17;340(3):916-28
• All: 10 reference(s)