Del(7Ffar2-Ffar3)1Soff Cytogenetic Marker Detail

Summary

• Symbol
  Del(7Ffar2-Ffar3)1Soff
• Name
  deletion, Chr 7, Stefan Offermanns 1

• Feature Type
  chromosomal deletion
• IDs
  MGI:5770479

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotypes from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for this deletion exhibit loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion and improved glucose tolerance in mice fed a high-fat diet.

References

• Summaries
  All 3

  Phenotypes 3
• Earliest
  J:227939 Tang C, et al., Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes. Nat Med. 2015 Feb;21(2):173-7
• Latest
  J:282380 Bachem A, et al., Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8(+) T Cells. Immunity. 2019 Aug 20;51(2):285-297.e5