Tg(tetO-ERBB2)#Jjz
Transgene Detail

Summary

• Symbol: Tg(tetO-ERBB2)#Jjz
• Name: transgene insertion, Jean J Zhao
• MGI ID: MGI:5775596
• Synonyms: tetO-HER2
• Transgene: Tg(tetO-ERBB2)#Jjz Location: unknown
• Alliance: Tg(tetO-ERBB2)#Jjz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-ERBB2)#Jjz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

• Mutation details: The wild-type human ERBB2 is under the control of seven direct repeats of the tetracycline (tet)-operator sequence. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:231766)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:231766 Goel S, et al., Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors. Cancer Cell. 2016 Mar 14;29(3):255-69
• All: 1 reference(s)