Tg(tetO-EGFR*T790M*L858R)19Kkw
Transgene Detail

Summary

• Symbol: Tg(tetO-EGFR*T790M*L858R)19Kkw
• Name: transgene insertion 19, Kwok-Kin Wong
• MGI ID: MGI:5781130
• Synonyms: T790M-L858R #19, Tet-op-EGFR TL
• Transgene: Tg(tetO-EGFR*T790M*L858R)19Kkw Location: unknown
• Alliance: Tg(tetO-EGFR*T790M*L858R)19Kkw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-EGFR*T790M*L858R)19Kkw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

• Mutation details: Seven direct repeats of the tetracycline (tet)-operator sequence drive the inducible expression of the human EGFR with the L858R, an erlotinib-sensitizing mutation, and the T790M resistance mutation. Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under control of a tissue-specific promoter can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. Four founders were generated: 17, 19, 24, and 29 and line 19 is entered as a representative line. (J:122849)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122849 Li D, et al., Bronchial and Peripheral Murine Lung Carcinomas Induced by T790M-L858R Mutant EGFR Respond to HKI-272 and Rapamycin Combination Therapy. Cancer Cell. 2007 Jul;12(1):81-93
• All: 13 reference(s)