Tg(Tyr)1999Lmon
Transgene Detail
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Symbol: |
Tg(Tyr)1999Lmon |
Name: |
transgene insertion 1999, Lluis Montoliu |
MGI ID: |
MGI:5787939 |
Synonyms: |
YRT2 |
Transgene: |
Tg(Tyr)1999Lmon Location: unknown
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Alliance: |
Tg(Tyr)1999Lmon page
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Transgene Type: |
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Transgenic (Reporter) |
Mutation: |
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Insertion
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Mutation details: The transgene contains a single copy of the entire mouse tyrosinase expression domain, including all five exons, the 5' and 3' untranslated regions (UTRs), and ~155 kb of 5' upstream sequences encompassing the locus control region (LCR) regulatory elements at -12 kb. Transgenic mice were generated by pronuclear injection of mouse oocytes with a 250-kb yeast artificial chromosome (YAC), YRT2, from a YAC library generated from strain C3H genomic DNA. Expression of the transgene is demonstrated by its complete rescue of the pigment phenotype of albino NMRI mice.
(J:4498)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:4498 Schedl A, et al., A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature. 1993 Mar 18;362(6417):258-61 |
All: |
8 reference(s) |
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