Tg(Tyr*)8748Lmon
Transgene Detail
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Symbol: |
Tg(Tyr*)8748Lmon |
Name: |
transgene insertion 8748, Lluis Montoliu |
MGI ID: |
MGI:5787964 |
Synonyms: |
YRT2deltaAB, YRT2deltaAB line 8748 |
Transgene: |
Tg(Tyr*)8748Lmon Location: unknown
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Alliance: |
Tg(Tyr*)8748Lmon page
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Transgene Type: |
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Transgenic (Reporter) |
Mutation: |
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Insertion
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Mutation details: This transgene contains two copies of the mouse tyrosinase gene, including all five exons, the 5' and 3' untranslated regions (UTs), and ~155 kb of upstream sequence encompassing the locus control region (LCR) regulatory elements at -12 kb, excluding the box A and box B elements. Transgenic mice were produced by pronuclear injection of mouse oocytes with the 250-kb yeast artificial chromosome (YAC) YRTdeltaAB, derived by homologous recombination of the YAC YRT2; YRT2 originated from a YAC library made from strain C3H genomic DNA. Expression of the transgene is demonstrated by its partial rescue of the pigment phenotype of albino NMRI mice.
(J:211470)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:211470 Giraldo P, et al., Artificial chromosome transgenesis in pigmentary research. Pigment Cell Res. 2002 Aug;15(4):258-64 |
All: |
1 reference(s) |
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