Tg(Myh6-Trim72)1Rpx
Transgene Detail

Summary

• Symbol: Tg(Myh6-Trim72)1Rpx
• Name: transgene insertion 1, Rui-Ping Xiao
• MGI ID: MGI:5792805
• Synonyms: MG53 h-TG
• Transgene: Tg(Myh6-Trim72)1Rpx Location: unknown
• Alliance: Tg(Myh6-Trim72)1Rpx page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Trim72)1Rpx expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Trim72

• Mutation details: The alpha-MHC promoter drives the cardiac-specific expression of the Trim72 cDNA. Two lines were generated, lines 1 and 2. (J:234132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Diabetic Cardiomyopathy J: 234132.

References

• Original: J:234132 Liu F, et al., Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor alpha. Circulation. 2015 Mar 3;131(9):795-804
• All: 2 reference(s)