Tg(tetO/Prnp-APP*Swe*Lon)9191Krz
Transgene Detail

Summary

• Symbol: Tg(tetO/Prnp-APP*Swe*Lon)9191Krz
• Name: transgene insertion 9191, Kathleen R Zahs
• MGI ID: MGI:5803807
• Synonyms: rTg9191
• Transgene: Tg(tetO/Prnp-APP*Swe*Lon)9191Krz Location: unknown
• Alliance: Tg(tetO/Prnp-APP*Swe*Lon)9191Krz page

Age-related amyloid beta plaque progression in Tg(tetO/Prnp-APP*Swe*Lon)9191Krz/0 Tg(Camk2a-tTA)1Mmay/0 mice

Show the 4 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/Prnp-APP*Swe*Lon)9191Krz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The 695 amino acid isoform of human amyloid precursor protein with the Swedish (K670N and M671L) and London (V717I) mutations is under the control of the tetracycline-response element and the Prnp promoter. Western blot analysis indicate transgene expression at a level four times that of the endogenous mouse protein in the membrane-enriched fraction of the brain. (J:235351)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:235351 Liu P, et al., Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique beta-Amyloid Oligomer Profile. PLoS One. 2015;10(5):e0126317
• All: 2 reference(s)