Tg(tetO-MYC,-OVAL)#Gtgm
Transgene Detail

Summary

• Symbol: Tg(tetO-MYC,-OVAL)#Gtgm
• Name: transgene insertion, Ines Guetgemann
• MGI ID: MGI:5811153
• Synonyms: c-myc/OVA tg, Tg(tetO-cmyc/OVA)
• Transgene: Tg(tetO-MYC,-OVAL)#Gtgm Location: unknown
• Alliance: Tg(tetO-MYC,-OVAL)#Gtgm page

Transgene origin

• Strain of Origin: C57BL/6J or C57BL/6J x (C57BL/6J x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The transgene contains a tetracycline responsive element, comprising seven tandem copies of the tetracycline operator (tetO), driving bidirectional expression of cDNAs encoding human MYC (melanocytomatosis oncogene; also called c-myc)(exons 2-3) and cytosolic chicken ovalbumin (OVAL; also called SERPINB14) from oppositely-oriented human cytomegalovirus (CMV) minimal promoters. (J:186226)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:186226 Ney JT, et al., Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Hepatology. 2009 Feb;49(2):471-81
• All: 1 reference(s)