Tg(PMP22)C3Fbas
Transgene Detail

Summary

• Symbol: Tg(PMP22)C3Fbas
• Name: transgene insertion C3, Frank Baas
• MGI ID: MGI:5817396
• Synonyms: C3-PMP
• Transgene: Tg(PMP22)C3Fbas Location: unknown
• Alliance: Tg(PMP22)C3Fbas page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PMP22)C3Fbas expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PMP22 (5376)

  Pmp22

  (MGI:97631)

• Mutation details: A yeast artificial chromosome (YAC) library was used to obtain a 560 kb BAC (49G7, also called 49H7) containing the entire human peripheral myelin protein 22 (PMP22) gene. Line C3 is derived from founder line C22 and carries 3-4 copies of the YAC, resulting in a milder phenotype than the higer copy number C22 mice. Overexpression of PMP22 is associated with Charcot-Marie-Tooth disease type 1A (CMT1A). (J:237901)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:237901 Verhamme C, et al., Myelin and axon pathology in a long-term study of PMP22-overexpressing mice. J Neuropathol Exp Neurol. 2011 May;70(5):386-98
• All: 3 reference(s)