Tg(Col1a1-Dkk1)1Hmk
Transgene Detail

Summary

• Symbol: Tg(Col1a1-Dkk1)1Hmk
• Name: transgene insertion 1, Henry M Kronenberg
• MGI ID: MGI:5818202
• Synonyms: Col1alpha2.3-Dkk1, Col1alpha-Dkk1, Dkk1-tg
• Transgene: Tg(Col1a1-Dkk1)1Hmk Location: unknown
• Alliance: Tg(Col1a1-Dkk1)1Hmk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Col1a1-Dkk1)1Hmk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dkk1 (MGI:1329040)

• Mutation details: A 2.3 kb promoter fragment of mouse Col1a1 was used to drive expression of the entire coding region of the mouse Dkk1 gene. Transgene expression is directed to osteoblastic lineage cells. (J:158620)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158620 Guo J, et al., Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 2010 Feb 3;11(2):161-71
• All: 3 reference(s)