Tg(Mpz*S63C)33Mes
Transgene Detail

Summary

• Symbol: Tg(Mpz*S63C)33Mes
• Name: transgene insertion 33, Albee Messing
• MGI ID: MGI:5824061
• Synonyms: line 130.3, Tg(MpzS63C)33Mes
• Transgene: Tg(Mpz*S63C)33Mes Location: unknown
• Alliance: Tg(Mpz*S63C)33Mes page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mpz*S63C)33Mes expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mpz (MGI:103177)	contains an S63C substitution

• Mutation details: This transgenic line expresses a mutated form of mouse Mpz. Codon 63 was engineered by site-directed mutagenesis to alter a serine to cysteine in the encoded protein. (J:105751)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105751 Wrabetz L, et al., Different intracellular pathomechanisms produce diverse Myelin Protein Zero neuropathies in transgenic mice. J Neurosci. 2006 Feb 22;26(8):2358-68
• All: 6 reference(s)