Tg(PDGFB-SNCA/EGFP)78Ema
Transgene Detail

Summary

• Symbol: Tg(PDGFB-SNCA/EGFP)78Ema
• Name: transgene insertion 78, Eliezer Masliah
• MGI ID: MGI:5824305
• Synonyms: PDNG78
• Transgene: Tg(PDGFB-SNCA/EGFP)78Ema Location: unknown
• Alliance: Tg(PDGFB-SNCA/EGFP)78Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(PDGFB-SNCA/EGFP)78Ema expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

  Expresses a SNCA/EGFP gene fusion product.

• Mutation details: The human alpha-synuclein cDNA without a stop codon is fused to the 5' end of EGFP and under the control of the PDGF-beta promoter. Five lines were obtained and the highest expresser lines, 75 and 78, were selected. Levels of human alpha-synuclein mRNA expression are equivalent to 3-fold the human brain levels in this line. (J:238692)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:238692 Rockenstein E, et al., Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein. J Neurosci Res. 2005 Apr 15;80(2):247-59
• All: 6 reference(s)