Tg(Ins2-Akt1*)3Mbb
Transgene Detail

Summary

• Symbol: Tg(Ins2-Akt1*)3Mbb
• Name: transgene insertion 3, Morris J Birnbaum
• MGI ID: MGI:5829193
• Synonyms: RIP-MyrAkt1
• Transgene: Tg(Ins2-Akt1*)3Mbb Location: unknown
• Alliance: Tg(Ins2-Akt1*)3Mbb page

Tg(Ins2-Akt1*)3Mbb/0 mice develop insulinomas

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Akt1*)3Mbb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Akt1	N-terminal myristoylation renders AKT1 constitutively active

• Tg(Ins2-Akt1*)3Mbb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat insulin II promoter drives the expression in pancreatic beta cells a form of Akt1 that has been rendered constitutively active by the addition of an N-terminal myristoylation sequence. Western blot confirmed expression of the transgene in pancreatic lysates. Two lines were generated, F3 and F7. (J:72216)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Insulinoma J:144599.

References

• Original: J:72216 Tuttle RL, et al., Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med. 2001 Oct;7(10):1133-7
• All: 3 reference(s)