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Tg(Ins2-Akt1*)3Mbb
Transgene Detail
Summary
Symbol: Tg(Ins2-Akt1*)3Mbb
Name: transgene insertion 3, Morris J Birnbaum
MGI ID: MGI:5829193
Synonyms: RIP-MyrAkt1
Transgene: Tg(Ins2-Akt1*)3Mbb  Location: unknown  
Alliance: Tg(Ins2-Akt1*)3Mbb page
Tg(Ins2-Akt1*)3Mbb/0 mice develop insulinomas

Show the 3 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins2-Akt1*)3Mbb expresses 1 gene
 
Tg(Ins2-Akt1*)3Mbb expression driven by 1 gene
 
Mutation detailsThe rat insulin II promoter drives the expression in pancreatic beta cells a form of Akt1 that has been rendered constitutively active by the addition of an N-terminal myristoylation sequence. Western blot confirmed expression of the transgene in pancreatic lysates. Two lines were generated, F3 and F7. (J:72216)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: Insulinoma J:144599.
References
Original:  J:72216 Tuttle RL, et al., Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nat Med. 2001 Oct;7(10):1133-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory