Tg(EEF1A1-Gnas*R201C)184Pabi
Transgene Detail

Summary

• Symbol: Tg(EEF1A1-Gnas*R201C)184Pabi
• Name: transgene lentiviral insertion 184, Paolo Bianco
• MGI ID: MGI:5883023
• Synonyms: EF1alpha-Gsalpha^R201C
• Transgene: Tg(EEF1A1-Gnas*R201C)184Pabi Location: unknown
• Alliance: Tg(EEF1A1-Gnas*R201C)184Pabi page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:240241
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(EEF1A1-Gnas*R201C)184Pabi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Gnas

• Mutation details: A lentiviral construct containing Gnas with an arginine to cysteine change at codon 201 (R201C) under the constitutive human elongation factor 1 alpha promoter was used to generate mice. Two founders were established: 184 and 33A. Line 184 is entered as a representative line. (J:240241)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:240241 Saggio I, et al., Constitutive expression of Gsalpha(R201C) in mice produces a heritable, direct replica of human fibrous dysplasia bone pathology and demonstrates its natural history. J Bone Miner Res. 2014 Nov;29(11):2357-68
• All: 1 reference(s)