Tg(TG-RET/NCOA4)3209Rstn
Transgene Detail

Summary

• Symbol: Tg(TG-RET/NCOA4)3209Rstn
• Name: transgene insertion 3209, Jay Rothstein
• MGI ID: MGI:5569734
• Synonyms: RET/PTC3
• Transgene: Tg(TG-RET/NCOA4)3209Rstn Location: unknown
• Alliance: Tg(TG-RET/NCOA4)3209Rstn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TG-RET/NCOA4)3209Rstn expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NCOA4 (8031)

  Ncoa4

  (MGI:1350932)

  human

  RET (5979)

  Ret	(MGI:97902)

• Mutation details: This transgene contained the bovine thyroglobulin (TG) promoter and a fusion product of human RET and human NCOA4, something often found in human papillary thyroid carcinomas. Line 3209 was one of three lines established and is entered as the representative line. (J:51366)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(TG-RET/NCOA4)3209Rstn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:51366 Powell DJ Jr, et al., The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res. 1998 Dec 1;58(23):5523-8
• All: 3 reference(s)