Tg(Myh6-CACNA1C)M1Aschw
Transgene Detail

Summary

• Symbol: Tg(Myh6-CACNA1C)M1Aschw
• Name: transgene insertion M1, Arnold Schwartz
• MGI ID: MGI:5904804
• Transgene: Tg(Myh6-CACNA1C)M1Aschw Location: unknown
• Alliance: Tg(Myh6-CACNA1C)M1Aschw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-CACNA1C)M1Aschw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CACNA1C (775)

  Cacna1c

  (MGI:103013)

• Mutation details: The full-length human L-type voltage-dependent calcium channel alpha 1C subunit coding sequence is under the control of the mouse alpha-myosin heavy chain promoter. Five founder lines were established, M1-M5. This line carries 8 copies of the transgene. Western blot analysis confirmed protein expression. (J:129494)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:129494 Muth JN, et al., Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction. J Biol Chem. 1999 Jul 30;274(31):21503-6
• All: 3 reference(s)