Tg(Myh6-Gnaq*Q209L)44Ejne
Transgene Detail

Summary

• Symbol: Tg(Myh6-Gnaq*Q209L)44Ejne
• Name: transgene insertion 44, EJ Neer
• MGI ID: MGI:5905048
• Synonyms: alphaq*44, Tgalphaq*44
• Transgene: Tg(Myh6-Gnaq*Q209L)44Ejne Location: unknown
• Alliance: Tg(Myh6-Gnaq*Q209L)44Ejne page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Gnaq*Q209L)44Ejne expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gnaq (MGI:95776)	this mutation renders Gnaq constitutively active

• Mutation details: The murine 5.5-kb alpha-myosin heavy chain promoter drives the cardiac-specific expression of mouse hemagglutinin (HA) epitope-tagged constitutively active (Q209L mutation) G protein alpha q subunit. This is a low expressing line. (J:204274)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:204274 Mende U, et al., Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13893-8
• All: 6 reference(s)