Tg(Myh6-Tpm1*E54K)30Dfw
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tpm1*E54K)30Dfw
• Name: transgene insertion 30, David F Wieczorek
• MGI ID: MGI:5906016
• Synonyms: alpha-TM54
• Transgene: Tg(Myh6-Tpm1*E54K)30Dfw Location: unknown
• Alliance: Tg(Myh6-Tpm1*E54K)30Dfw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tpm1*E54K)30Dfw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tpm1 (MGI:98809)

• Mutation details: The cardiac specific mouse alpha-MHC promoter drives the expression of a mouse mutant alpha-tropomyosin striated muscle specific cDNA with a single nucleotide change, GAA>AAA, corresponding to an amino acid substitution of a glutamic acid to lysine at codon 54 (Glu54Lys). Five lines were generated; 67, 71, 76, 95, and 30. This line has a copy number of approximately 174 and is the high-expressing line. (J:137813)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:137813 Rajan S, et al., Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res. 2007 Jul 20;101(2):205-14
• All: 4 reference(s)