Tg(Myh7-Phc1)#Yota
Transgene Detail

Summary

• Symbol: Tg(Myh7-Phc1)#Yota
• Name: transgene insertion, Yoshihiro Takihara
• MGI ID: MGI:5906059
• Synonyms: BetaMHC-rae28
• Transgene: Tg(Myh7-Phc1)#Yota Location: unknown
• Alliance: Tg(Myh7-Phc1)#Yota page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh7-Phc1)#Yota expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Phc1 (MGI:103248)

• Mutation details: The mouse beta-MHC promotor drives heart-sepcific expression of the full-length mouse cDNA. Two lines were established, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:75968)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Phc1^tm1Os/Phc1^tm1Os Tg(Myh7-Phc1)#Yota/0	involves: 129S2/SvPas * C57BL/6
tg2  Disease Model	Tg(Myh7-Phc1)#Yota/0	involves: C57BL/6

Phenotypes:

Affected Systems	cx1	tg2
show or hide all annotated terms
cardiovascular system	√	√
abnormal cardiovascular system morphology	√
abnormal heart morphology	√
abnormal myocardial fiber morphology		√
thin myocardium		√
atrial septal defect	√
ventricular septal defect	√
enlarged heart		√
dilated cardiomyopathy		√
decreased heart left ventricle muscle contractility		√
congestive heart failure		√
cellular		√
abnormal mitochondrial crista morphology		√
abnormal mitochondrial shape		√
increased cardiomyocyte apoptosis		√
growth/size/body		√
enlarged heart		√
homeostasis/metabolism		√
abnormal atrial thrombosis		√
edema		√
ascites		√
pleural effusion		√
mortality/aging		√
premature death		√
muscle		√
abnormal myocardial fiber morphology		√
thin myocardium		√
dilated cardiomyopathy		√
decreased heart left ventricle muscle contractility		√
increased cardiomyocyte apoptosis		√
abnormal sarcomere morphology		√
abnormal M line morphology		√
abnormal Z line morphology		√
respiratory system		√
pleural effusion		√
respiratory distress		√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg2
dilated cardiomyopathy IDs dilated cardiomyopathy       DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193 Close	√

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:75968 Koga H, et al., Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy. Lab Invest. 2002 Apr;82(4):375-85
• All: 1 reference(s)