Tg(Myh6-Tnni3*)1Ammu
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*)1Ammu
• Name: transgene insertion 1, Anne M Murphy
• MGI ID: MGI:5906192
• Synonyms: TnI 1-193
• Transgene: Tg(Myh6-Tnni3*)1Ammu Location: unknown
• Alliance: Tg(Myh6-Tnni3*)1Ammu page

Transgene origin

• Strain of Origin: C57BL/6 x A/J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnni3*)1Ammu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tnni3 (29248)

  Tnni3

  (MGI:98783)

  truncated protein

• Mutation details: The cardiac-specific 5.5-kb murine alpha-MHC promoter drives the expression of a rat cardiac troponin I cDNA truncated at lysine 193 which is missing the 17 COOH-terminal residues. Three lines were generated which have 9 to 13 copies of the transgene. Founder line 1 is the representative line. (J:59433)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:59433 Murphy AM, et al., Transgenic mouse model of stunned myocardium. Science. 2000 Jan 21;287(5452):488-91
• All: 3 reference(s)