Tg(Myh6-Snai1)B10Jcc
Transgene Detail

Summary

• Symbol: Tg(Myh6-Snai1)B10Jcc
• Name: transgene insertion B10, James C Cross
• MGI ID: MGI:5906252
• Synonyms: MHC-Snail
• Transgene: Tg(Myh6-Snai1)B10Jcc Location: unknown
• Alliance: Tg(Myh6-Snai1)B10Jcc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Snai1)B10Jcc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Snai1 (MGI:98330)

• Mutation details: The mouse Snai1 cDNA is under the control of the cardiac specific mouse myosin heavy chain alpha promoter. Three lines were established: B10, B18 and B26. Founder lines B18 and B26 died from cardiac failure while B10 survived. This line has a copy number of 2. (J:126850)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:126850 Hesse M, et al., Dilated cardiomyopathy is associated with reduced expression of the cardiac sodium channel Scn5a. Cardiovasc Res. 2007 Aug 1;75(3):498-509
• All: 2 reference(s)