Tg(Myh6-Rxra)41Pcn
Transgene Detail

Summary

• Symbol: Tg(Myh6-Rxra)41Pcn
• Name: transgene insertion 41, Pierre Chambon
• MGI ID: MGI:5906918
• Transgene: Tg(Myh6-Rxra)41Pcn Location: unknown
• Alliance: Tg(Myh6-Rxra)41Pcn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Rxra)41Pcn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rxra (MGI:98214)

• Mutation details: 5.5 kb of the myosin heavy chain alpha gene, including the promoter and the first 3 untranslated exons, drive the heart-specific expression of mouse Rxra cDNA linked to a 1.3-kb fragment from the human progesterone receptor 3' UTR region to be used as a tag. Two lines were generated: 41 and 54.This line has a copy number of 16 and is the high expressing line. (J:60351)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
cn1	Rxra^tm1Ipc/Rxra^tm1Ipc Tg(Myh6-Rxra)41Pcn/0	involves: 129S2/SvPas
tg2  Disease Model	Tg(Myh6-Rxra)41Pcn/0	Not Specified

Phenotypes:

Affected Systems	cn1	tg2
show or hide all annotated terms
cardiovascular system	√	√
abnormal myocardial fiber morphology		√
myocardial fiber degeneration		√
enlarged heart		√
ventricular hypoplasia	√
dilated cardiomyopathy		√
cellular		√
abnormal respiratory electron transport chain		√
growth/size/body		√
enlarged heart		√
homeostasis/metabolism		√
abnormal cardiac thrombosis		√
pleural effusion		√
mortality/aging	√	√
premature death		√
lethality throughout fetal growth and development, complete penetrance	√
muscle		√
abnormal myocardial fiber morphology		√
myocardial fiber degeneration		√
dilated cardiomyopathy		√
abnormal sarcomere morphology		√
abnormal M line morphology		√
abnormal Z line morphology		√
respiratory system		√
pleural effusion		√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	tg2
dilated cardiomyopathy IDs dilated cardiomyopathy       DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193 Close	√

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:60351 Subbarayan V, et al., RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses. J Clin Invest. 2000 Feb;105(3):387-94
• All: 1 reference(s)