Tg(Myh6-LMNA*E82K)35Lizh
Transgene Detail

Summary

• Symbol: Tg(Myh6-LMNA*E82K)35Lizh
• Name: transgene insertion 35, Lianfeng Zhang
• MGI ID: MGI:5907285
• Synonyms: Lmna^E82K
• Transgene: Tg(Myh6-LMNA*E82K)35Lizh Location: unknown
• Alliance: Tg(Myh6-LMNA*E82K)35Lizh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-LMNA*E82K)35Lizh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LMNA (4000)

  Lmna	(MGI:96794)

• Mutation details: The human gene with a G to A substitution resulting in the E82K mutation is under the cardiac-specific alpha-MHC promoter. Line 30 and 35 were analyzed. (J:167734)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:167734 Lu D, et al., LMNA E82K mutation activates FAS and mitochondrial pathways of apoptosis in heart tissue specific transgenic mice. PLoS One. 2010;5(12):e15167
• All: 1 reference(s)