Tg(MT2A-TGFBR2)4Rser
Transgene Detail

Summary

• Symbol: Tg(MT2A-TGFBR2)4Rser
• Name: transgene insertion 4, Rosa Serra
• MGI ID: MGI:3620964
• Synonyms: MT-DNIIR-4, MTR4
• Transgene: Tg(MT2A-TGFBR2)4Rser Location: unknown
• Alliance: Tg(MT2A-TGFBR2)4Rser page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(MT2A-TGFBR2)4Rser expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFBR2 (7048)

  Tgfbr2

  (MGI:98729)

• Mutation details: The transgene contains a truncated human TGFBR2 gene under the control of the human MT2A promoter. The truncated receptor contains the extracellular, transmembrane, and juxtamembrane domains. Most of the cytoplasmic domain including the kinase domain is deleted. This mutant receptor acts as a dominant-negative mutation. The promoter contains four metal responsive elements and a beta-globin TATA element, splice sites, and polyadenylation signal. Five lines, 4, 15, 27, 28, and 30, were generated. (J:44579)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:44579 Serra R, et al., Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol. 1997 Oct 20;139(2):541-52
• All: 4 reference(s)