Tg(HBx-HCV)C5Tto
Transgene Detail

Summary

• Symbol: Tg(HBx-HCV)C5Tto
• Name: transgene insertion C5, Takeshi Tokuhisa
• MGI ID: MGI:5907641
• Synonyms: Px-core
• Transgene: Tg(HBx-HCV)C5Tto Location: unknown
• Alliance: Tg(HBx-HCV)C5Tto page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The hepatitis B virus X gene (Px) promoter drives the expression of the hepatitis C virus-core cDNA (HCV-1b strain). Northern blot and Western blot analysis confirmed mRNA and protein expression in livers and various tissues including thymus, spleen, brain, heart, lung, kidney intestine, and testis. Two lines, C5 and C8 were established Line C5 is the high expressing line. (J:243110)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243110 Honda A, et al., HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice. J Hepatol. 2000 Sep;33(3):440-7
• All: 2 reference(s)