Tg(CD2-Cxcr3)833Arsa
Transgene Detail

Summary

• Symbol: Tg(CD2-Cxcr3)833Arsa
• Name: transgene insertion 833, Abhay Satoskar
• MGI ID: MGI:5907840
• Synonyms: CXCR3^Tg
• Transgene: Tg(CD2-Cxcr3)833Arsa Location: unknown
• Alliance: Tg(CD2-Cxcr3)833Arsa page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Cxcr3)833Arsa expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Cxcr3 (MGI:1277207)

• Mutation details: The transgenic construct contains mouse cDNA containing Cxcr3 inserted into the second exon of and therefore under the control of the hCD2 minigene, which consists of human CD2 gene promoter and exon 1 with a mutant ATG start codon, first intron, 3' UTR polyA signal, and flanking sequence. Flow cytometric analyis in thymus, lymph nodes, and spleen confirms that protein is expressed constitutively in almost all T cells. (J:242971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:242971 Oghumu S, et al., Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response. Infect Immun. 2015 Jan;83(1):67-76
• All: 2 reference(s)