Tg(Myh6-HBEGF)#Iko
Transgene Detail

Summary

• Symbol: Tg(Myh6-HBEGF)#Iko
• Name: transgene insertion, Issei Komuro
• MGI ID: MGI:5907885
• Transgene: Tg(Myh6-HBEGF)#Iko Location: unknown
• Alliance: Tg(Myh6-HBEGF)#Iko page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-HBEGF)#Iko expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The human diphtheria toxin receptor, pro-HB-EGF (precursor of heparin-binding EGF-like growth factor), is under the control of the cardiac-specific alpha-myosin heavy chain promoter. Administration of diphtheria toxin induces ablation of transgene-expressing cardiomyocytes. Two lines were generated, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:93335)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:93335 Akazawa H, et al., Diphtheria toxin-induced autophagic cardiomyocyte death plays a pathogenic role in mouse model of heart failure. J Biol Chem. 2004 Oct 24;279(39):41095-103
• All: 1 reference(s)