Tg(Myh6-MYL2*E22K)4Dsc
Transgene Detail

Summary

• Symbol: Tg(Myh6-MYL2*E22K)4Dsc
• Name: transgene insertion 4, Danuta Szczesna-Cordary
• MGI ID: MGI:5908892
• Synonyms: Tg-E22K
• Transgene: Tg(Myh6-MYL2*E22K)4Dsc Location: unknown
• Alliance: Tg(Myh6-MYL2*E22K)4Dsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MYL2*E22K)4Dsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYL2 (4633)

  Myl2	(MGI:97272)

• Mutation details: The mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third drives the cardiac-specific expression of a mutated human myosin regulatory light chain 2 cDNA that contains an amino acid substitution of lysine for glutamic acid at position 22 (E22K, a familial hypertrophic cardiomyopathy-linked mutation). An N-terminal myc sequence was added to aid in identification of the human transgenic protein. Two lines were generated, L2 and L4. Line 4 is entered as the representative line. (J:101467)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:101467 Szczesna-Cordary D, et al., The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice. J Cell Sci. 2005 Aug 15;118(Pt 16):3675-83
• All: 4 reference(s)