Tg(Myh7-Ptpn11*Q510E)#Krnz
Transgene Detail

Summary

• Symbol: Tg(Myh7-Ptpn11*Q510E)#Krnz
• Name: transgene insertion, Maike Krenz
• MGI ID: MGI:5909085
• Transgene: Tg(Myh7-Ptpn11*Q510E)#Krnz Location: unknown
• Alliance: Tg(Myh7-Ptpn11*Q510E)#Krnz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh7-Ptpn11*Q510E)#Krnz expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ptpn11 (MGI:99511)

• Mutation details: The murine beta-myosin heavy chain promoter drives the expression of a Ptpn11 cDNA which contains the amino acid substitution of glutamate for glutamine at position 510 (Q510E). Q510E is a dominant-negative loss-of-function mutation. The beta-myosin heavy chain promoter drives transgene expression starting around E11 and the transgene is expressed stably and continuously after birth. Several lines were generated including: 1, 3, 5, and 6, however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:181656)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:181656 Schramm C, et al., The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Am J Physiol Heart Circ Physiol. 2012 Jan;302(1):H231-43
• All: 3 reference(s)