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Tg(Myh6-Ptpn11*Q510E)#Krnz
Transgene Detail
Summary
Symbol: Tg(Myh6-Ptpn11*Q510E)#Krnz
Name: transgene insertion, Maike Krenz
MGI ID: MGI:5909086
Transgene: Tg(Myh6-Ptpn11*Q510E)#Krnz  Location: unknown  
Alliance: Tg(Myh6-Ptpn11*Q510E)#Krnz page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Ptpn11*Q510E)#Krnz expresses 1 gene
 
Mutation detailsThe murine alpha-myosin heavy chain promoter drives the expression of a Ptpn11 cDNA which contains the amino acid substitution of glutamate for glutamine at position 510 (Q510E). Q510E is a dominant-negative loss-of-function mutation. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:181656)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
 
Phenotypes:
Affected Systems
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cardiovascular system
N
cardiovascular system phenotype
N
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:181656 Schramm C, et al., The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Am J Physiol Heart Circ Physiol. 2012 Jan;302(1):H231-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory