Tg(Myh6-Ptpn11*Q510E)#Krnz
Transgene Detail
|
Symbol: |
Tg(Myh6-Ptpn11*Q510E)#Krnz |
Name: |
transgene insertion, Maike Krenz |
MGI ID: |
MGI:5909086 |
Transgene: |
Tg(Myh6-Ptpn11*Q510E)#Krnz Location: unknown
|
Alliance: |
Tg(Myh6-Ptpn11*Q510E)#Krnz page
|
|
|
Transgene Type: |
|
Transgenic (Dominant negative, Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(Myh6-Ptpn11*Q510E)#Krnz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Ptpn11 (MGI:99511) |
|
|
|
|
Mutation details: The murine alpha-myosin heavy chain promoter drives the expression of a Ptpn11 cDNA which contains the amino acid substitution of glutamate for glutamine at position 510 (Q510E). Q510E is a dominant-negative loss-of-function mutation. The pound symbol (#) is used when line is not specified and/or lines are pooled.
(J:181656)
|
|
|
Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
---|
Loading... | | | | |
|
Phenotypes: |
Affected Systems |
|
|
cardiovascular system
|
N
|
cardiovascular system phenotype
|
N
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:181656 Schramm C, et al., The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Am J Physiol Heart Circ Physiol. 2012 Jan;302(1):H231-43 |
All: |
1 reference(s) |
|