Tg(Myh6-MYL3*A57G)#Dsc
Transgene Detail

Summary

• Symbol: Tg(Myh6-MYL3*A57G)#Dsc
• Name: transgene insertion, Danuta Szczesna-Cordary
• MGI ID: MGI:5909257
• Synonyms: Tg-A57G
• Transgene: Tg(Myh6-MYL3*A57G)#Dsc Location: unknown
• Alliance: Tg(Myh6-MYL3*A57G)#Dsc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MYL3*A57G)#Dsc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYL3 (4634)

  Myl3	(MGI:97268)

• Mutation details: The human ventricular essential light chain cDNA with an alanine to glycine mutation at residue 57 (A57G) is under the control of the mouse alpha-myosin heavy chain promoter. Lines L1, L5, and L2 were generated, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:178377)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:178377 Muthu P, et al., Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction. FASEB J. 2011 Dec;25(12):4394-405
• All: 5 reference(s)