Tg(Myh6-LDB3*S196L)93Mva
Transgene Detail

Summary

• Symbol: Tg(Myh6-LDB3*S196L)93Mva
• Name: transgene insertion 93, Matteo Vatta
• MGI ID: MGI:5910333
• Transgene: Tg(Myh6-LDB3*S196L)93Mva Location: unknown
• Alliance: Tg(Myh6-LDB3*S196L)93Mva page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-LDB3*S196L)93Mva expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LDB3 (11155)

  Ldb3	(MGI:1344412)

• Mutation details: The human cardiac-specific isoform 4 cDNA containing a leucine for serine substitution at amino acid 196 (S196L) in exon 4 fused to a 6His-V5 tag is under the control of the mouse alpha-myosin heavy chain. Two lines were generated 93 and 94. Line 93 is entered as a representative line. (J:243711)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:243711 Li Z, et al., A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy. Circ Arrhythm Electrophysiol. 2010 Dec;3(6):646-56
• All: 2 reference(s)