Tg(TLR4)5271Haj
Transgene Detail

Summary

• Symbol: Tg(TLR4)5271Haj
• Name: transgene insertion 5271, Adeline Hajjar
• MGI ID: MGI:5911243
• Transgene: Tg(TLR4)5271Haj Location: unknown
• Alliance: Tg(TLR4)5271Haj page

Transgene origin

• Strain of Origin: C3H or C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TLR4)5271Haj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TLR4 (7099)

  Tlr4	(MGI:96824)

• Mutation details: The transgene was designed with a human bacterial artificial chromosome (BAC) RP11-150L1 containing the entire human TLR4 gene. Founder line 5271 was established and carries two copies of the transgene. The BAC contains at least 50 Kb of human genomic sequences flanking the TLR4 gene. (J:194866)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

BAC DNA was microinjected into (C57BL/6 x C3H)F1 x C57BL/6 (B6C3 x C57BL/6) fertilized oocytes. (J:194866)

References

• Original: J:194866 Hajjar AM, et al., Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica. PLoS Pathog. 2012;8(10):e1002963
• All: 3 reference(s)