Tg(Ckm-Sgcg)4Mcn
Transgene Detail

Summary

• Symbol: Tg(Ckm-Sgcg)4Mcn
• Name: transgene insertion 4, Elizabeth M McNally
• MGI ID: MGI:5911931
• Synonyms: MCKgsg line 4
• Transgene: Tg(Ckm-Sgcg)4Mcn Location: unknown
• Alliance: Tg(Ckm-Sgcg)4Mcn page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-Sgcg)4Mcn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sgcg (MGI:1346524)

• Mutation details: The full-length murine gamma-sarcoglycan cDNA is under the control of muscle-specific creatine kinase promoter followed by bovine growth hormone termination and polyadenylation signals. Four lines were generated (1-4). Line 4 carries approximately 36 copies relative to the endogenous gene and is a high expressing line. (J:128649)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128649 Zhu X, et al., Overexpression of gamma-sarcoglycan induces severe muscular dystrophy. Implications for the regulation of Sarcoglycan assembly. J Biol Chem. 2001 Jun 15;276(24):21785-90
• All: 1 reference(s)