Tg(Myh6-Tnni3*R193H)594Jmme
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnni3*R193H)594Jmme
• Name: transgene insertion 594, Joseph M Metzger
• MGI ID: MGI:5912298
• Transgene: Tg(Myh6-Tnni3*R193H)594Jmme Location: unknown
• Alliance: Tg(Myh6-Tnni3*R193H)594Jmme page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnni3*R193H)594Jmme expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnni3 (MGI:98783)

• Mutation details: The murine cardiac troponin I cDNA with a single amino acid conversion of arginine to histidine at codon 193 (R193H) and a 3 flag epitope tag is under the control of the cardiac specific murine alpha-myosin heavy chain promoter. (J:186721)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186721 Davis J, et al., Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy. J Mol Cell Cardiol. 2012 Sep;53(3):446-57
• All: 2 reference(s)