Tg(tetO-TARDBP*A315T)13Lmit
Transgene Detail

Summary

• Symbol: Tg(tetO-TARDBP*A315T)13Lmit
• Name: transgene insertion 13, Lars M Ittner
• MGI ID: MGI:5922010
• Transgene: Tg(tetO-TARDBP*A315T)13Lmit Location: unknown
• Alliance: Tg(tetO-TARDBP*A315T)13Lmit page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(tetO-TARDBP*A315T)13Lmit expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TARDBP (23435)

  Tardbp

  (MGI:2387629)

  Mutated human gene resulting in Ala315Thr substitution

• Mutation details: The human cDNA was engineered with a c.1077G>A point mutation, resulting in codon 315 changing from alanine to threonine (p.A315T or p.Ala315Thr). This mutation is associated with familial amyotrophic lateral sclerosis (ALS) in humans. A construct comprising the tetracycline inducible tetO promoter, the human cDNA and an SV40 poly signal, was injected into the pronuclei of fertilized C57BL/6 oocytes. Two lines, this line and numbers 6, were selected for further study. (J:245760)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:245760 Ke YD, et al., Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathol. 2015 Nov;130(5):661-78
• All: 3 reference(s)