Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl
Transgene Detail

Summary

• Symbol: Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl
• Name: transgene insertion 7, Richard Z Lin
• MGI ID: MGI:6105945
• Synonyms: GalphaqQ209L-hbER
• Transgene: Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl Location: unknown
• Alliance: Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Myh6-Gnaq*Q209L/Esr1*)7Rzl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gnaq (MGI:95776)

• Mutation details: The mouse alpha myosin heavy chain promoter drives the expression of a mutant Gnaq with the Q209L mutation fused to a mutant hormone-binding domain of the murine estrogen receptor in which replacement of glycine by arginine at amino acid position 525 renders the fusion proteins activity inducible by 4-hydroxytamoxifen, but unresponsive to natural estrogen. Three lines, 5, 7, and 11, were established. Line 7 is the high-expressing line. (J:104100)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104100 Fan G, et al., A transgenic mouse model of heart failure using inducible Galpha q. J Biol Chem. 2005 Dec 2;280(48):40337-46
• All: 1 reference(s)