Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb
Transgene Detail

Summary

• Symbol: Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb
• Name: transgene insertion 10, Jean Hebert
• MGI ID: MGI:6108317
• Synonyms: FGFR3-GOF
• Transgene: Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb Location: unknown
• Alliance: Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fgfr3 (MGI:95524)	Fgfr3*K650E

• Mutation details: The transgenic construct was designed with a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), a loxP-flanked STOP cassette, the mouse Fgfr3 (fibroblast growth factor receptor 3) cDNA containing a lysine to glutamic acid substitution at residue 650 (K650E) rendering Fgfr3 constitutively active, followed by an IRES-eGFP fluorescent protein sequence. (J:212260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:212260 Kang W, et al., Astrocyte activation is suppressed in both normal and injured brain by FGF signaling. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2987-95
• All: 3 reference(s)