Tg(CAG-Calr)#Mlk
Transgene Detail

Summary

• Symbol: Tg(CAG-Calr)#Mlk
• Name: transgene insertion, Marek Michalak
• MGI ID: MGI:6108898
• Synonyms: CRT-TG
• Transgene: Tg(CAG-Calr)#Mlk Location: unknown
• Alliance: Tg(CAG-Calr)#Mlk page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Calr)#Mlk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Calr (MGI:88252)

• Mutation details: The transgene consists of the cytomegalovirus early enhancer/chicken beta-actin promoter, a loxP flanked chloramphenicol acetyltransferase (cat) gene followed by cDNA encoding HA-tagged mouse calreticulin. Cre mediated recombination results in excision of the cat gene and subsequent production of calreticulin. (J:199413)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:199413 Lee D, et al., Calreticulin induces dilated cardiomyopathy. PLoS One. 2013;8(2):e56387
• All: 3 reference(s)