Tg(TTR)#Jbux
Transgene Detail

Summary

• Symbol: Tg(TTR)#Jbux
• Name: transgene insertion, Joel Buxbaum
• MGI ID: MGI:6110833
• Transgene: Tg(TTR)#Jbux Location: unknown
• Alliance: Tg(TTR)#Jbux page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TTR)#Jbux expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ttr (MGI:98865)

• Mutation details: This transgene contains the human transthyretin gene containing the endogenous general promoter, liver specific enhancer, and tissue specific regulator. This line contains approximately 90 copies of the human insert per diploid genome. Northern blot confirmed expression of mRNA in the liver, eye, and brain and small amounts in tongue, kidney, heart, skeletal muscle, and stomach. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:68458)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:68458 Teng MH, et al., Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis. (Erratum: 2002; 82(3):241). Lab Invest. 2001 Mar;81(3):385-96
• All: 2 reference(s)