Tg(Ins2-IAPP)L13Gjsc
Transgene Detail

Summary

• Symbol: Tg(Ins2-IAPP)L13Gjsc
• Name: transgene insertion L13, Garth JS Cooper
• MGI ID: MGI:6111355
• Synonyms: hA/hIAPP
• Transgene: Tg(Ins2-IAPP)L13Gjsc Location: unknown
• Alliance: Tg(Ins2-IAPP)L13Gjsc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-IAPP)L13Gjsc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Iapp (MGI:96382)

• Tg(Ins2-IAPP)L13Gjsc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat insulin 2 promoter drives the expression of the human amylin/islet amyloid polypeptide cDNA. Southern blotting indicates that hemizygous mice have approximately 36 +/-7 copies of the transgene. Northern blot analysis from various organs confirmed pancreas-specific expression of RNA transcripts. (J:142009)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:142009 Wong WP, et al., Spontaneous diabetes in hemizygous human amylin transgenic mice that developed neither islet amyloid nor peripheral insulin resistance. Diabetes. 2008 Oct;57(10):2737-44
• All: 4 reference(s)