Rr45 Other Genome Feature Detail

Summary

• Symbol
  Rr45
• Name
  regulatory region 45
• Synonyms
  MFCS4

• Feature Type
  enhancer
• IDs
  MGI:6117281

Location &
Maps

• Sequence Map
  Chr5:29392493-29393491 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, Syntenic

Strain
Comparison

• SNPs within 2kb
  104 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  14 phenotypes from 1 allele in 1 genetic background
  2 phenotypes from multigenic genotypes
  6 phenotype references
  

• All Mutations and Alleles
  3
• Targeted
  3
• Genomic Mutations
  1 involving Rr45
• Find Mice (IMSR)
  2 strains or lines available

Mice lacking the MFCS4 enhancer of Shh exhibit early postnatal lethality and abnormal pharangeal development.

References

• Summaries
  All 7

  Phenotypes 6
• Earliest
  J:148018 Sagai T, et al., A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
• Latest
  J:295947 Ohki S, et al., Transforming Growth Factor-Beta and Sonic Hedgehog Signaling in Palatal Epithelium Regulate Tenascin-C Expression in Palatal Mesenchyme During Soft Palate Development. Front Physiol. 2020;11:532